Concept and plan of effect-based monitoring and effect directed analysis (EDA) of chemicals towards EWS

Establishment of an early warning system (EWS) for the identification of new and existing potentially hazardous substances is a key component of PARC. An EWS includes early warning monitoring toolboxes to identify chemical hazards in a broad range of biotic and abiotic matrices and products with a special focus on aqueous environment that may be associated with an unacceptable health risk. Effect-based monitoring (EBM) and effect-directed analysis (EDA) are identified as key toolboxes for prioritizing chemical hazards in various matrices including water, soil, sediment, sludge, air, dust, aquatic and terrestrial biota, human samples, products like food contact materials, and food. This report gives an overview of i) sampling strategies, ii) sample preparation methods for bioassays and chemical analysis, iii) EBM using bioassays, iv) chemical analytical methods including target, suspect and nontarget screening, v) EDA and iceberg modelling, and vi) future perspectives and needs for an EWS.