{"id":117390,"date":"2026-09-11T17:03:31","date_gmt":"2026-09-11T15:03:31","guid":{"rendered":"https:\/\/nilu.gnist.dev\/publikasjoner\/estimating-time-varying-pcb-exposures-using-person-specificpredictions-to-supplement-measured-values-a-comparison-ofobserved-and-predicted-values-in-two-cohorts-of-norwegianwomen\/"},"modified":"2026-09-11T17:03:31","modified_gmt":"2026-09-11T15:03:31","slug":"estimating-time-varying-pcb-exposures-using-person-specificpredictions-to-supplement-measured-values-a-comparison-ofobserved-and-predicted-values-in-two-cohorts-of-norwegianwomen","status":"publish","type":"nva_publication","link":"https:\/\/nilu.gnist.dev\/en\/publications\/estimating-time-varying-pcb-exposures-using-person-specificpredictions-to-supplement-measured-values-a-comparison-ofobserved-and-predicted-values-in-two-cohorts-of-norwegianwomen\/","title":{"rendered":"Estimating Time-Varying PCB Exposures Using Person-Specific\r\nPredictions to Supplement Measured Values: A Comparison of\r\nObserved and Predicted Values in Two Cohorts of Norwegian\r\nWomen"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Background: Studies on health effects of polychlorinated biphenyls (PCBs) call for an understanding of past and present human exposure. Time-resolved mechanistic models may<br \/>\nsupplement information on concentrations in individuals obtained from measurements and\/or statistical approaches, if they can be shown to reproduce empirical data.<br \/>\nObjectives: Here we evaluate the capability of one such mechanistic model to reproduce measured PCB concentrations in individual Norwegian women. We also assess individual life<br \/>\ncourse concentrations.<br \/>\nMethods: Concentrations of four PCB congeners in pregnant women (n= 310, sampled in 2007-2009) and postmenopausal women (n= 244, 2005) were compared to person-specific predictions obtained with CoZMoMAN, an emission-based environmental fate and human food-Chain bioaccumulation model. Person-specific predictions were also made with statistical regression models including dietary and lifestyle variables and concentrations.<br \/>\nResults: CoZMoMAN accurately reproduced medians and ranges of measured concentrations in the two study groups. Further, rank correlations between measurements and predictions from both CoZMoMAN and regression analyses were strong (Spearman`s r &gt;0.67). Precision in quartile assignments from predictions was strong overall as evaluated by Weighted Cohen`s Kappa &gt;0.6. Simulations indicated large inter-individual differences in concentrations experienced in the past.<br \/>\nConclusions: The mechanistic model reproduced all measurements of PCB concentrations within a factor of ten and subject ranking and quartile assignments were overall largely consistent, although weak within each study group. Contamination histories for individuals predicted by<br \/>\nCoZMoMAN revealed variation between study subjects, particularly in the timing of peak concentrations. Mechanistic models provide individual PCB exposure metrics that could serve as valuable supplements to measurements.<\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_id":"","_status":"PUBLISHED","_sync_date":"2026-09-11 14:36:36","footnotes":""},"nva_tax_category":[1099],"class_list":["post-117390","nva_publication","type-nva_publication","status-publish","hentry","nva_tax_category-scientific-journal-publication"],"acf":[],"_links":{"self":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication\/117390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication"}],"about":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/types\/nva_publication"}],"version-history":[{"count":0,"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication\/117390\/revisions"}],"wp:attachment":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/media?parent=117390"}],"wp:term":[{"taxonomy":"nva_tax_category","embeddable":true,"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_tax_category?post=117390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}