{"id":118853,"date":"2026-09-11T21:49:26","date_gmt":"2026-09-11T19:49:26","guid":{"rendered":"https:\/\/nilu.gnist.dev\/publikasjoner\/a-pooled-analysis-of-host-factors-that-affect-nucleotide-excision-repair-in-humans\/"},"modified":"2026-09-11T21:49:26","modified_gmt":"2026-09-11T19:49:26","slug":"a-pooled-analysis-of-host-factors-that-affect-nucleotide-excision-repair-in-humans","status":"publish","type":"nva_publication","link":"https:\/\/nilu.gnist.dev\/en\/publications\/a-pooled-analysis-of-host-factors-that-affect-nucleotide-excision-repair-in-humans\/","title":{"rendered":"A pooled analysis of host factors that affect nucleotide excision repair in humans"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Nucleotide excision repair (NER) is crucial for repairing bulky lesions and crosslinks in DNA caused by exogenous and endogenous genotoxins. The number of studies that have considered DNA repair as a biomarker is limited, and therefore one of the primary objectives of the European COST Action hCOMET (CA15132) was to assemble and analyse a pooled database of studies with data on NER activity. The database comprised 738 individuals, gathered from 5 laboratories that ran population studies using the comet-based in vitro DNA repair assay. NER activity data in peripheral blood mononuclear cells were normalized and correlated with various host-related factors, including sex, age, body mass index (BMI), and smoking habits. This multifaceted analysis uncovered significantly higher NER activity in female participants compared to males (1.08\u2005\u00b1\u20050.74 vs. 0.92\u2005\u00b1\u20050.71; P\u2005=\u2005.002). Higher NER activity was seen in older subjects (&gt;30 years), and the effect of age was most pronounced in the oldest females, particularly those over 70 years (P\u2005=\u2005.001). Females with a normal BMI (&lt;25 kg\/m2) exhibited the highest levels of NER, whereas the lowest NER was observed in overweight males (BMI\u2005\u2265\u200525 kg\/m2). No independent effect of smoking was found. After stratification by sex and BMI, higher NER was observed in smoking males (P\u2005=\u2005.017). The biological implication of higher or lower repair capacity remains unclear; the inclusion of DNA repair as a biomarker in molecular epidemiological trials should elucidate the link between health and disease status.\n<\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_id":"","_status":"PUBLISHED","_sync_date":"2026-09-11 14:48:28","footnotes":""},"nva_tax_category":[1099],"class_list":["post-118853","nva_publication","type-nva_publication","status-publish","hentry","nva_tax_category-scientific-journal-publication"],"acf":[],"_links":{"self":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication\/118853","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication"}],"about":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/types\/nva_publication"}],"version-history":[{"count":0,"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication\/118853\/revisions"}],"wp:attachment":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/media?parent=118853"}],"wp:term":[{"taxonomy":"nva_tax_category","embeddable":true,"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_tax_category?post=118853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}