{"id":89970,"date":"2026-06-26T13:10:55","date_gmt":"2026-06-26T11:10:55","guid":{"rendered":""},"modified":"2026-06-26T13:23:09","modified_gmt":"2026-06-26T11:23:09","slug":"0198cc63060a-768df5b2-f996-4fc7-8502-8ba64fd4e183","status":"publish","type":"nva_publication","link":"https:\/\/nilu.gnist.dev\/en\/publications\/0198cc63060a-768df5b2-f996-4fc7-8502-8ba64fd4e183\/","title":{"rendered":"Combining plasma measurements and mechanistic modeling to explore the effect of POPs on type 2 diabetes mellitus in Norwegian women"},"content":{"rendered":"<p class=\"wp-block-paragraph\">The number of studies on persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM) is growing steadily. Although concentrations of many POPs in humans have decreased substantially, only some studies consider temporal and inter-individual changes in POP concentrations when assessing exposure. Here we combined plasma measurements with mechanistic modelling to generate complementary exposure measures to our single blood draw after disease diagnosis.<br \/>\nBlood was collected between 2003-2006 from 106 subjects with T2DM and 106 age-matched controls, and POP concentrations were compared after adjustment for relevant risk factors and multiple testing. Area under the curve (AUC) of PCB-153 from birth until  age 18, representing early-life exposure, and AUC from birth until  time of diagnosis were generated as well as examples of life-time exposure trajectories using a mechanistic exposure model. The rank sum of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs, OR=16.9 (95% CI: 3.05- 93.6)) as well as \u03b2-hexachlorocyclohexane (\u03b2-HCH, OR=203.8 (95% CI: 11.5- 3620)) and 1, 1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p\u2019-DDE, OR=11.3 (95% CI: 2.55- 49.9)) were associated with T2DM. Neither of the AUCs reflecting early life exposure and total life-time exposure at the time of diagnosis were associated with the disease. The predicted life course trajectories display clear differences within and between individuals in the past and suggest that a single blood draw provide limited information on POP exposure earlier in life. The predicted AUCs for PCB-153 did not support the positive association between T2DM and measured blood concentration of certain POPs. This may suggest that the model is either too simplistic and\/or that strength of the association may vary through life and with time to\/past diagnosis. <\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_id":"","_status":"PUBLISHED","_sync_date":"2026-06-26 13:10:55","footnotes":""},"nva_tax_category":[1059],"class_list":["post-89970","nva_publication","type-nva_publication","status-publish","hentry","nva_tax_category-scientific-journal-publication"],"acf":[],"_links":{"self":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication\/89970","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication"}],"about":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/types\/nva_publication"}],"version-history":[{"count":1,"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication\/89970\/revisions"}],"predecessor-version":[{"id":89971,"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_publication\/89970\/revisions\/89971"}],"wp:attachment":[{"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/media?parent=89970"}],"wp:term":[{"taxonomy":"nva_tax_category","embeddable":true,"href":"https:\/\/nilu.gnist.dev\/en\/wp-json\/wp\/v2\/nva_tax_category?post=89970"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}