Publikasjoner

Genotoxicity of nanomaterials: Advanced in vitro models and high throughput methods for human hazard assessment—a review

Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal or (during mitosis) whole genome level. The study of mechanisms leading to genotoxicity is crucially important, as well as the detection of potentially genotoxic compounds. We consider the current state of the art and describe here the main endpoints applied in standard human in vitro models as well as new advanced 3D models that are closer to the in vivo situation. We performed a literature review of in vitro studies published from 2000–2020 (August) dedicated to the genotoxicity of nanomaterials (NMs) in new models. Methods suitable for detection of genotoxicity of NMs will be presented with a focus on advances in miniaturization, organ-on-a-chip and high throughput methods.

Genotoxicity of nanosilver. Impact of size and surface properties.

Dusinska, M.; Huk, A.; Izak-Nau, E.; Reidy, B.; El Yamani, N.; Lynch, I.

Genotoxicity testing of nanomaterial. New testing strategies. NILU F

Dusinska, M.

Genotoxicity testing of PLGA-PEO nanoparticles in TK6 cells by means of the comet assay and the cytokinesis-block micronucleus assay.

Kazimirova, A.; Magdolenova, Z.; Barancokova, M.; Staruchova, M.; Volkovova, K.; Dusinska, M.

Gentiana asclepiadea and Armoracia rusticana can modulate the adaptive response induced by zeocin in human lymphocytes.

Hudecova, A.; Hasplova, K.; Kellovska, L.; Ikreniova, M.; Miadokova, E.; Galova, E.; Horvathova, E.; Vaculcikova, D.; Gregan, F.; Dusinska, M.

Gentiana asclepiadea protects human cells against oxidation DNA lesions.

Hudecova, A.; Hasplova, K.; Miadokova, E.; Magdolenova, Z.; Rinna, A.; Collins, A. R.; Galova, E.; Vaculcikova, D.; Gregan, F.; Dusinska, M.

Geochemistry of PM10 over Europe during the EMEP intensive measurement periods in summer 2012 and winter 2013.

Alastuey, A.; Querol, X.; Aas, W.; Lucarelli, F.; Pérez, N.; Moreno, T.; Cavalli, F.; Areskoug, H.; Balan, V.; Catrambone, M.; Ceburnis, D.; Cerro, J. C.; Conil, S.; Gevorgyan, L.; Hueglin, C.; Imre, K.; Jaffrezo, J.-L.; Leeson, S. R.; Mihalopoulos, N.; Mitosinkova, M.; O'Dowd, C. D.; Pey, J.; Putaud, J.-P.; Riffault, V.; Ripoll, A.; Sciare, J.; Sellegri, K.; Spindler, G.; Yttri, K. E.

Geoengineering skulle kunna skapa ett mer orättvist klimat

Muri, Helene (intervjuobjekt)

Världens klimatsystem hänger ihop, så geoengineering för bättre klimat i en region kan påverka andra regioner negativt. Men vem styr och tar beslut om ...

Geographic information systems (GIS). NILU F

Sivertsen, B.; Marawska, L.

Geographic variability of nitrate deposition and preservation over the Greenland Ice Sheet.

Burkhart, J.F.; Bales, R.C.; McConnell, J.R.; Hutterli, M.A.; Frey, M.M.

Geographical dependence observed in blocking high influence on the stratospheric variability through enhancement and suppression of upward planetary-wave propagation.

Nishii, K.; Nakamura, H.; Orsolini, Y.J.

Geographical dependence observed in blocking high influence on the stratospheric variability. NILU F

Nishii, K.; Nakamura, H.; Orsolini, Y.J.